Dapoxetine, marketed as Priligy, is used to treat premature ejaculation (PE), a condition that affects men between the ages of 18 and 64.

Inhibiting the serotonin transporter, Dapoxetine increases serotonin’s action at the postsynaptic cleft, increasing ejaculatory delay. 

As an antidepressant drug, dapoxetine was originally developed as a selective serotonin-reuptake inhibitor (SSRI). On the other hand, Dapoxetine is rapidly absorbed and excreted from the body in contrast to other SSRIs. Because of this, it is an excellent choice for the treatment of PE, but not for the treatment of depression.

How Does Dapoxetine Work?

Although the exact mechanism by which dapoxetine affects premature ejaculation is unknown, it is thought to work by inhibiting serotonin transporters and thus increasing serotonin’s action at pre- and postsynaptic receptors.

Various areas of the central nervous system control human ejaculation (CNS). The ejaculatory pathway begins with a spinal reflex that is activated by stimuli from the male genitalia at the thoracolumbar and lumbosacral levels of the spinal cord. These signals are transmitted to the brain stem, which is then influenced by a number of brain nuclei, including the medial preoptic and paraventricular nuclei.

Dapoxetine administration inhibits the ejaculatory expulsion reflex at the supraspinal level by modulating the activity of lateral paragigantocellular nucleus (LPGi) neurons in anesthetized male rats. Although it is unclear whether dapoxetine acts directly on LPGi or on the descending pathway in which LPGi is located, these effects cause an increase in pudendal motor neuron reflex discharge (PMRD) latency — in layman’s terms, it delays ejaculation.

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Does Dapoxetine Work For PE?

Premature ejaculation medication Priligy has a lot of scientific backing to back it up, but does it work? 

In a nutshell, and based on recent studies, the answer is yes. Dapoxetine has been shown to be effective in preventing ejaculation. In fact, Dapoxetine has been extensively studied for its ability to delay ejaculation. 

Participants in the studies had their time-to-ejaculation lengthened by between 0.5 and 3.4 minutes, depending on the study. Study participants taking placebos also saw an increase in their time to ejaculation, but the increase was only minimal.

What Are The Side Effects of Dapoxetine?

What Are The Side Effects of Dapoxetine?

Dapoxetine side effects include nausea, headaches, and dizziness as well as more specific ones such as constipation and diarrhea. 

According to the manufacturer, some users have reported the following side effects: 

  • Feeling dizzy or faint when you get up from a sitting position. 
  • Nerve twitching or shaking 
  • Blurred vision or discomfort in the eyes 
  • Ear ringing or changes in one’s ability to hear 
  • Hypertension (higher blood pressure) 
  • anxiety, nervousness, indifference, and/or sadness 
  • The inability to fall or stay asleep as a result of abnormal dreams and/or nightmares. 

Some men who take Dapoxetine may experience symptoms of an allergic reaction.

In addition to the side effects mentioned above, some men have reported side effects such as: 

  • Nausea 
  • Headache 
  • Dizziness 
  • Decreased desire for sex

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How To Take Dapoxetine (Priligy)

You must never take Dapoxetine 60mg unless it has been prescribed by a doctor who is qualified to do so. 

Dapoxetine, in contrast to other medications, is meant to be taken only when necessary. 30mg tablets are usually prescribed per prescription, with a total of 30 tablets. 

There are a few general rules of thumb to follow if you have a prescription for Priligy or Dapoxetine tablets: 

Take them between one and three hours before sex. 

Do not break or chew the pills; instead, swallow them whole. 

Be sure to drink plenty of water before you take the medication. 

Taking more than one tablet in 24 hours is not permitted. 

Taking Priligy on a full stomach appears to have no effect on its efficacy, but the time it takes for the medication to take effect can be affected. 

If you take Dapoxetine, don’t drink any grapefruit juice for at least 24 hours. Grapefruit juice alters the metabolization of Dapoxetine, resulting in an increase in Dapoxetine levels in the blood.

How Long Does Dapoxetine Take to Work?

How Long Does Dapoxetine Take to Work?

One of the things that users dislike about Dapoxetine is that you never know how long it will take for the medication to take effect. 

The medication should be taken one to three hours before sex, according to the manufacturer. There are numerous factors that can influence the medication’s one to three-hour timeframe of action. To make matters worse, predicting how long it will be before you have sex with a partner can be difficult. 

Before relying on Dapoxetine to work for you during sex, it’s best to do a few test runs to see how long it takes for the medication to work for you. It may take some trial and error to determine the exact time you should take the medicine before having sex.

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Is Dapoxetine Available in the US?

Priligy Dapoxetine is still unavailable in the United States as of 2020. 

As a result, even if you have been formally diagnosed with premature ejaculation, you will be unable to obtain a prescription for the medication from a doctor. 

In 2004, Johnson & Johnson applied to the FDA for approval of Priligy, but the application was denied in 2005. It was thought at the time that approval had been delayed due to a lack of clinical evidence of efficacy and long-term safety. 

Several clinical trials, both in and outside of the United States, have since concluded. 

It only takes a quick Google search to find ads for Dapoxetine (or even Priligy) on Amazon, as well as a slew of websites claiming to sell the drug. However, the majority of the products you find will not be genuine. 

Note that Dapoxetine uses and Priligy have not been approved by the FDA in the United States, so anything you find locally is unlikely to be a reliable product.

Takeaway

Priligy is a drug that is effective in the treatment of PE. According to the studies mentioned above, the drug is well tolerated and has a high safety profile. It adds 3-4 minutes to the average duration of intercourse. It’s worth noting that dapoxetine can be used as an emergency “pill on demand.” This drug stands out among other PE treatments for its lack of significant side effects and effectiveness. In addition to dapoxetine, other treatments are less effective or have a high number of side effects.

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